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Head of Laboratory

Lab Team

The main areas of research

  1. Ecological and physiological interactions between entomopathogenic fungi and insects. Immune reactions of hosts during development of mycoses caused by fungi with various host range and different pathogenic strategy.
  2. Development of fungal infections in insects during different periods of ontogenesis. Role of epicuticular hydrocarbons and fatty acids in the fungal infections.
  3. Interactions in multicomponent systems: insect hosts fungi bacteria parasitoids plants.
  4. Metagenomics of insect's symbionts. Influence of gut microorganisms and gut immunity on development of mycoses and toxicoses caused by natural and synthetic insecticides, as well as combinations of fungi and insecticides.
  5. Diversity of entomopathogenic fungi in Siberia and Far East of Russia.
  6. Molecular phylogeny of parasites

Main objects

Fungi - Metarhizium, Beauveria, Isaria, Cordyceps

Insects - wax moth Galleria mellonella, Colorado potato beetle Leptinotarsa decemlineata, locusts Locusta, Calliptamus, mosquitoes Aedes, Culex, Anopheles and non-target aquatic invertebrates (Odonata, Hemiptera)


Projects of RAS, RSF, RFBR

Selected publications


Alekseev A.A., Tyurin M., Khairov K., Kotina O., Odeyanko V., Danilov V., Kryukov V. Glupov V., Characterization and Biological Action of Avermectin Granules on the Moroccan Locust, Dociostaurus maroccanus (Orthoptera: Acrididae) // Journal of Economic Entomology. 2019. DOI: 10.1093/jee/toz206

Tomilova O.G., Yaroslavtseva O.N., Ganina M.D., Tyurin M.V., Chernyak E.I., Senderskiy I.V., Noskov Y.A., Polenogova O.V., Akhanaev Y.B., Kryukov V.Yu., Glupov V.V., Morozov S.V. Changes in antifungal defence systems during the intermoult period in the Colorado potato beetle // Journal of Insect Physiology. 2019. V. 116. P. 106117. DOI: 10.1016/j.jinsphys.2019.05.003

Polenogova O.V., Kabilov M.R., Tyurin M.V., Rotskaya U.N., Krivopalov A.V., Morozova V.V., Mozhaitseva K., Kryukova N.A., Alikina T., Kryukov V.Yu., Glupov V. V. Parasitoid envenomation alters the Galleria mellonella midgut microbiota and immunity, thereby promoting fungal infection // Scientific Reports. 2019. 9:4012. https://doi.org/10.1038/s41598-019-40301-6.


Kryukov V.Yu, Tomilova O. G., Yaroslavtseva O. N., Wen T.-C., Kryukova N. A., Polenogova O. V., Tokarev Y. S., Glupov V. V. Temperature adaptations of Cordyceps militaris, impact of host thermal biology and immunity on mycosis development // Fungal Ecology 2018. V. 35. P. 98-107. pdf

Krukov V.Yu., Tomilova O.G., Luzina O.A., Yaroslavtseva O.N., Akhanaev Yu.B., Tyurin M.V., Duisembekov B.A, Salakhutdinov N.F., Glupov V.V. Effects of fluorine-containing usnic acid and fungus Beauveria bassiana on the survival and immune-physiological reactions of Colorado potato beetle larvae // Pest Management Science. V. 74. P. 598-606. pdf

Kryukov V., Yaroslavtseva O. N., Whitten M.M.A, Tyurin M. V., Ficken K., Greig C., Melo N.R, Glupov V.V., Dubovskiy I. M., Butt T. Fungal infection dynamics in response to temperature in the lepidopteran insect Galleria mellonella // Insect Science. 2018. V. 25 (3). P. 454-466. pdf

Belevich O., Yurchenko Y., Krivopalov A., Kryukov V., Glupov V. Effects of Metarhizium robertsii on the bloodsucking mosquito Aedes flavescens and non?target predatory insects (Odonata) // Journal of Applied Entomology. 2018. V.142 (6). P. 632-635. pdf

Kryukov V.Yu. , Kryukova N.A., Tyurin M.V., Yaroslavtseva O.N., Glupov V. V. Passive vectoring of entomopathogenic fungus Beauveria bassiana among the wax moth Galleria mellonella larvae by the ectoparasitoid Habrobracon hebetor females // Insect Science. 2018. V. 25. P.643-654. pdf

Vorontsova Y.L., Slepneva I.A., Alekseev A.A., Kryukov V.Y., Tyurin M.V., Glupov V.V. The effect of entomopathogenic fungi Metarhizium robertsii of different virulence on the generation of reactive oxygen species in Galleria mellonella larvae // Invertebrate Survival Journal 2018. 15:276-284.

Zha L., Huang S.-K., Xiao Y.-P., Boonmee S., Eungwanichayapant P., McKenzie E., Kryukov V., Wu X.-L., Hyde K., Wen T. An evaluation of common Cordyceps (Ascomycetes) species found in Chinese markets // International Journal of Medicinal Mushrooms. 2018. V. 20 N. 12. P. 1149-1162. pdf


Yaroslavtseva O.N., Dubovskiy I.M., Khodyrev V.P., Duisembekov B.A., Kryukov V.Yu., Glupov V.V. Immunological mechanisms of synergy between fungus Metarhizium robertsii and bacteria Bacillus thuringiensis ssp. morrisoni on Colorado potato beetle larvae // Journal of Insect Physiology 2017. V. 96. P. 1420 pdf

Novgorodova T., Kryukov V. Quarantining behaviour of ants towards infected aphids as an antifungal mechanism in ant-aphid interactions // Entomologia Experimentalis et Applicata. 2017. V162 (3) P. 293-301. pdf

Kryukov V., Yaroslavtseva O., Tyurin M., Akhanaev Y., Elisaphenko E., Wen T.-C., Tomilova O., Tokarev Y., Glupov V. Ecological preferences of Metarhizium spp. from Russia and neighboring territories and their activity against Colorado potato beetle larvae // Journal of Invertebrate Pathology (2017) V. 149 . P. 1-7.pdf

Belevich O.E., Yurchenko Y.A., Glupov V.V., Kryukov V.Yu. Effect of entomopathogenic fungus Metarhizium robertsii on non-target organisms, water bugs (Heteroptera: Corixidae, Naucoridae, Notonectidae) // Applied Entomology and Zoology. 2017. V. 52 (3) pp 439445 pdf

Kerchev I.A., Kryukova N.A., Kryukov V.Yu., Glupov V.V. Entomoparasitic nematodes Sychnotylenchus sp. (Anguinidae) on the four-eyed fir bark beetle Polygraphus proximus: effects on the host's immunity and its susceptibility to Beauveria bassiana // Invertebrate Survival Journal 14: 324-329, 2017


Tomilova O.G., Kryukov V.Y., Duisembekov B.A., Yaroslavtseva O.N., Tyurin M.V., Kryukova N.A., Skorokhod V., Dubovskiy I.M., Glupov V.V. Immune-physiological aspects of synergy between avermectins and the entomopathogenic fungus Metarhizium robertsii in Colorado potato beetle larvae. Journal of Invertebrate Pathology, 2016. 140. pp. 8-15. DOI: 10.1016/j.jip.2016.08.008 pdf

M.V. Tyurin, V.Yu. Kryukov, O.N. Yaroslavtseva, E.A. Elisafenko, I.M.Dubovskiy, V.V. Glupov. Comparative analysis of immune responses in Colorado potato beetle larvae during development of mycoses caused by Metarhizium robertsii, M. brunneum, and M. pemphigi.Journal of Evolutionary Biochemistry and Physiology, 2016, Vol. 52, No. 3, pp. 252260. pdf

Lavikainen A., Iwaki T., Haukisalmi V., Konyaev S.V., Casiraghi M., Dokuchaev N.E., Galimberti A., Halajian A., Henttonen H., Ichikawa-Seki M., Itagaki T., Krivopalov A.V., Meri S., Morand S., Nareaho A., Olsson G.E., Ribas A., Terefe Y., Nakao M. Reappraisal of Hydatigera taeniaeformis (Batsch, 1786) (Cestoda: Taeniidae) sensu lato with description of Hydatigera kamiyai n. sp. Int J Parasitol. 2016 May;46(5-6):361-74. doi: 10.1016/j.ijpara.2016.01.009. Epub 2016 Mar 5. pdf

Novikov E., Petrovski D., Mak V.. Kondratyuk E., Krivopalov A., Moshkin M. Variability of whipworm infection and humoral immune response in a wild population of mole voles (Ellobius talpinus Pall.). Parasitology Research. 2016 Apr. DOI: 10.1007/s00436-016-5042-1 pdf


Novikov E., Kondratyuk E., Petrovski D., Krivopalov A., Moshkin M. Effects of parasites and antigenic challenge on metabolic rates and thermoregulation in northern red-backed voles (Myodes rutilus). Parasitol Research. 2015 Sep 5. DOI: 10.1007/s00436-015-4691-9 pdf

Kryukov V. Yu., Yaroslavtseva O. N., Surina E. V., Tyurin M. V., Dubovskiy I. M., Glupov V. V. 2015. Immune reactions of the greater wax moth, Galleria mellonella L. (Lepidoptera, Pyralidae) larvae under combined treatment of the entomopathogens Cordyceps militaris (L.: Fr.) Link and Beauveria bassiana (Bals.-Criv.) Vuill. // Entomological Review, 2015, Vol. 95, No. 6, pp. 693698. pdf

Martemyanov V.V., Pavlushin S.V., Dubovskiy I.M., Yushkova Y.V., Morosov S.V., Chernyak E.I., Efimov V.M., Ruuhola T., Glupov V.V. 2015. Asynchrony between Host Plant and Insects Defoliator within a Tritrophic System: The Role of Herbivore Innate Immunity // PLoS ONE 10(6): e0130988. doi:10.1371/journal.pone.0130988 pdf

Martemyanov V.V., Pavlushin SV, Dubovskiy I.M., Belousova IA, Yushkova YV, Morosov SV, Chernyak E.I., Glupov V.V. 2015. Leaf Surface Lipophilic Compounds as One of the Factors of Silver Birch Chemical Defense against Larvae of Gypsy Moth. // PLoS ONE 10(3): e0121917. doi:10.1371/journal.pone.0121917 pdf


Khodyrev V.P., Dubovskiy I.M., Kryukov V.Y., Glupov V.V. 2014. Susceptibility of Anopheles messeae Fall. and Culex pipiens pipiens L. larvae to entomopathogenic fungi Metarhizium // Contemporary Problems of Ecology 3. P. 435-438. pdf

Kryukov V.Yu., Yaroslavtseva O.N., Dubovskiy I.M., Tyurin M.V., Kryukova N.A., Glupov V.V. 2014. Insecticidal and immunosuppressive effect of ascomycete Cordyceps militaris on the larvae of the colorado potato beetle Leptinotarsa decemlineata // Biology Bulletin 41(3):276283. pdf


Dubovskiy I.M., Whitten M.M.A., Yaroslavtseva O.N., Greig C., Kryukov V.Y., Grizanova E.V., Mukherjee K., Vilcinskas A., Glupov V.V., Butt T.M. Can Insects Develop Resistance to Insect Pathogenic Fungi? PLoS ONE. 2013. 8(4). pdf

Kryukov V.Yu., Kryukova N.A., Glupov V.V. Susceptibility of Galleria mellonella Larvae to Anamorphic Entomopathogenic Ascomycetes under Envenomation and Parasitization by Habrobracon hebetor. Russian Journal of Ecology, 2013, Vol. 44, No. 1, pp. 8992. DOI: 10.1134/S1067413613010074 pdf

Konyaev S.V., Yanagida T., Nakao M., Ingovatova G.M., Shoykhet Y.N., Bondarev A.Y., Odnokurtsev V.A., Loskutova K.S., Lukmanova G.I., Dokuchaev N.E., Spiridonov S.E., Alshinecky M.V., Sivkova T.N., Andreyanov O.N., Abramov S.A., Krivopalov A.V., Karpenko S.V., Lopatina N.V., Dupal T.A., Sako Y., Ito A. Genetic diversity of Echinococcus spp. in Russia. Parasitology. 2013. Nov; 140(13):1637-47. pdf

Dubovskiy I.M., Whitten M.M.A., Kryukov V.Y., Yaroslavtseva O.N., Grizanova E.V., Greig C., Mukherjee K., Vilcinskas A., Mitkovets P.V., Glupov V.V., Butt T.M. 2013. More than a colour change: insect melanism, disease resistance and fecundity // Proceedings of the Royal Society B: Biological Sciences. 280: 20130584. doi 10.1098/rspb.2013.0584280 pdf


Dubovskiy I. M., Slyamova N. D., Kryukov V. Yu., Yaroslavtseva O. N., Levchenko M. V., Belgibaeva A. B., Adilkhankyzy A., Glupov V.V. The activity of nonspecific esterases and glutathione-S-transferase inLocusta migratoria larvae infected with the fungus Metarhizium anisopliae (Ascomycota, Hypocreales) Entomological Review, 2012. V. 92, No. 1, pp. 27-32. pdf

Martemyanov V.V., Dubovskiy I.M., Belousova I.A., Pavlushin S.V., Domrachev D.V., Rantala M.J., Salminen J-P., Bakhvalov S.A., Glupov V.V. Rapid induced resistance of silver birch affects both innate immunity and performance of gypsy moths: the role of plant chemical defenses. Arthropod-Plant Interactions, 2012. 6, 507518. pdf

Martemyanov V.V., Dubovskiy I.M., Rantala M.J., Salminen J-P., Belousova I.A., Pavlushin S.V., Bakhvalov S.A., Glupov V.V. The effects of delay induced response of silver birch on gypsy moth's performance, immune responses and resistance against baculovirus. Journal of chemical ecology, 2012. 38(3):295-305. pdf

Kryukov V.Yu., Yaroslavtseva O.N., Elisaphenko E.A., Mitkovets P.V., Lednev G.R., Duisembekov B.A., Zakian S.M., Glupov V.V. Change in the Temperature Preferences of Beauveria bassiana sensu lato isolates in the Latitude Gradient of Siberia and Kazakhstan. Microbiology. 2012. Vol. 81. No. 4. pp. 453459. pdf


Dubovskiy I.M., Sliamova N.D., Kryukov V.J.; Jaroslavceva O.N., Levchenko M.V.; Belgibaeva A.B., Adilxankizi A., Glupov V.V. Activity of nonspecific esterases and glutathione S-transferase of Locusta migratoria larvae during fungi infections Metarhizium anisopliae. Russian Journal of Zoology, 2011. 90, V. 11, pp. 13601364. pdf

Kryukov V.Yu., Dubovskiy I.M., Yaroslavtseva O.N., Levchenko M.V., Slyamova N.D., Belgibaeva A.B. Khodyrev V.P. , Lednev G.R., Glupov V.V. Analisis of two strategies of entomopathogenic fungus Metarhizium anisopliae. Mycology and Phytopathology, 2011. 44, V2, pp. 164-177.

Kryukov V.Yu., Yaroslavtseva O.N., Lednev G.R., Borisov B. A. Local Epizootics Caused by Teleomorphic Cordycipitoid Fungi (Ascomycota:Hypocreales) in Populations of Forest Lepidopterans and Sawflies of the SummerAutumn Complex in Siberia. Microbiology, 2011, Vol. 80, No. 2. P. 286296.


Kryukov V.Yu., Yaroslavtseva O.N., Levchenko M.V., Lednyov G.R., Glupov V.V. Phenotypic Variability of Environmental Isolates of the Entomopathogenic Fungus Beauveria bassiana. Microbiology. 2010. Vol. 79. No. 2. pp. 265269.


Bakhvalov S.A., Martemyanov V.V., Kukushkina T.A., Vysochina G.I. The Dynamics of Phenolic Compounds and Soluble Sugars in the Leaves of the Silver Birch (Betula pendula Roth) after Defoliation and Their Significance in Entomological Plant Resistance. Biology Bulletin, 2009. Vol. 36, No. 5, pp. 449454.

Martemyanov V.V., Bakhvalov S.A., Rantala M.J., Dubovskiy I.M., Shults E.E., Belousova I.A., Strelnikov A.G., and Glupov V.V. 2009 The Response of Gypsy Moth (Lymantria dispar L.) Larvae Infected with Nuclear Polyhedrosis Virus to Induced Resistance in Birch (Betula pendula Roth.). Russian Journal of Ecology, Vol. 40, No. 6, pp. 434439.

Kryukov V.Yu., Khodyrev V.P., Yaroslavtseva O.N., Kamenova A.S., Duisembekov B.A., Glupov V.V. Synergistic action of entomopathogenic Hyphomycetes and the bacteria Bacillus thuringiensis ssp. morrisoni in the infection of Colorado Potato Beetle Leptinotarsa decemlineata. Applied Biochemistry and Microbiology. 2009. Vol. 45. No. 5. pp. 511516.


Dubovskiy I.M., Martemyanov B.B., Vorontsova Y.L., Rantala M.J., Gryzanova E.V., Glupov V.V. 2008. Effect of the bacterial infection on the antioxidant activity and lipid peroxidation in the midgut of larvae Galleria mellonella L. (Lepidoptera, Pyralidae). Comparative Biochemistry and Physiology. .148. 1-5.

Krukov V.J., Martemyanov V.V., Polovinka M.P., Luzina O.A., Dubovskiy I.M., Serebrov V.V., Hodirev V.P., Malarchuk A.A., Gerber O.N., Jaroslavceva O.N., Bojarisheva E.A., Levchenko M.V., Glupov V.V., Salakhutdinov N.F., Tolstikov G.A. 2008. Usnic acid - promising synergist for biopesticide containing entomopathogenic microorganisms. Doklady Biological Sciences. 423, 2.


Martemyanov, V.V., Bakhvalov S.A.. Interrelationships of plantinsectparasite systems and their influence on the development and population dynamics of forest defoliators. Eurasian entomology journal, 2007. V. 6. P. 205221 (Review article in Russian with English summary).

Kryukov V.Yu., Lednyov G.R., Dubovskiy I.M., Serebrov V.V., Levchenko .., Khodyrev V.P., Sagitov A.O., Glupov V.V. 2007. New approaches of insect biological control with entomopathogenic hyphomycetes (Deuteromycota, Hyphomycetes). Euroasian Entomological Journal, 6(2): 195204 + IV (in Russian).


Martemyanov V.V., Bakhvalov S.A., Dubovskiy I.M., Glupov V.V., Salakhutdinov N.F., Tolstikov G.A. 2006. Effect of tannic acid on the development and resistance of the gypsy moth Lymantria dispar L. to viral infection // Doklady Biochemistry and Biophysics V. 409. pp. 219222.

Bakhvalov S.A., Martemyanov V.V., Shults E.E., Markina Zh.O., Tolstikov G.A.. The response of gypsy moth (Lymantria dispar L., Lym., Lep.) to content of phytochemicals in birch (Betula pendula Roth) leaves. // Entomologicheskoe obozrenie 2006. V. 65. P. 753-761. (In Russian with English summary).

Serebrov V.V. , O.N. Gerber, A.A. Malyarchuk, V.V. Martemyanov, A.A. Alekseev, V.V. Glupov. Effect of entomopathogenic fungi on detoxification enzyme activity in greater wax moth Galleria mellonella L. (Lepidoptera, Pyralidae) and role of detoxification enzymes in development of insect resistance to entomopathogenic fungi // Biology Bulletin. 2006. V. 33. P. 581586.

Bakhvalov S.A. , V.N. Bakhvalova, V.V. Martemyanov. The role of trophic factor in population dynamics of insects: analysis of the problem // Uspekhi sovremennoj biologii. 2006. V. 126. P. 4960. (in Russian).


Shults E.E., Bakhvalov S.A., Martemyanov V.V., Petrova T.N., Syromyatnikova I.N., Shakirov M.M., and Tolstikov G.A. Effects of natural and artificial defoliation on the content and composition of extractive substances in birch leaves //Applied Biochemistry and Microbiology, 2005. V. 41. 1. pp. 9498.

Glupov V.V., Slepneva I.A., Serebrov V.V., Khvoschevskay M.F., Martemyanov V.V., Dubovskiy I.M., Khramtsov V.V. Influence of the fungal infection on the production of reactive metabolites and the antioxidant state of haemolymph of Galleria mellonella larvae // Russian Entmol.J., 2003. V.12 P.103-108.

Bakhvalov S.A., Ilyinykh A.V., Jimerikin V.N., Martemjanov V.V. Population dynamics of nun moth (Lymantria monacha L., Lym., Lep.) and gypsy moth (Lymantria dispar L., Lym., Lep.): the role of resource and virus infection // Eurasian entomological journal, 2002. 1, 1. P. 101-108.